Chorionic bump în sarcina incipientă: un aspect ecografic inedit. Prezentare de caz şi review al literaturii

 Chorionic bump at early stage of gestation: an interesting ultrasound finding. Case report and literature review

First published: 24 martie 2022

Editorial Group: MEDICHUB MEDIA

DOI: 10.26416/Gine.35.1.2022.6123


Chorionic bump represents a rare abnormality of the gestational sac and, until now, there has been conflicting evidence related to its association with adverse perinatal outcomes. It appears as a bulge from the choriodecidual surface into the gestational sac which often decreases in size with time and rarely persists beyond the first trimester. Our case report presents and discusses a chorionic bump diagnosed early in pregnancy. After adequate counseling, the patient opted for termination of pregnancy; the embryonic karyotype was normal (46, XY). Taking into accoung the relative rarity of this entity, we review the available literature in order to raise awareness on this interesting sonographic finding.

chorionic bump, miscarriage, ultrasound, case report


Chorionic bump reprezintă o anomalie rară a sacului ges­ta­ţio­nal, posibil asociată cu o serie de complicaţii perinatale. As­pec­tul sonografic este acela al unei formaţiuni protruzive în in­te­rio­rul sacului gestaţional de la nivelul suprafeţei corio­de­ci­dua­le ale cărei dimensiuni de obicei se reduc pe parcursul sar­ci­nii, rareori persistând în trimestrul al treilea. În acest ar­ti­col vom prezenta un caz diagnosticat precoce în sarcină cu chorionic bump. Pacienta a fost consiliată adecvat privind po­si­bi­le­le complicaţii obstetricale asociate acestui diagnostic, iar aceasta a decis întreruperea la cerere a cursului sarcinii. Tes­ta­rea genetică a produsului de concepţie a evidenţiat un ca­rio­tip masculin normal (46, XY). Având în vederea raritatea aces­tui aspect ecografic, vom prezenta un review al datelor pu­bli­ca­te până în prezent în literatura de specialitate referitoare la chorionic bump.


A chorionic bump (CB), which was first reported by Harris et al. in 2006, has often been described as an irregular, convex bulge from the choriodecidual surface into the first-trimester gestational sac(1). It is tipically located within the thickest part of the developing placenta, chorion frondosum(2).

The incidence of CB is between 1.5 and 7 per 1000 preg­nancies(3) and the viable pregnancy outcome rate is reported between less than 50% to 65% and even higher (83%) if the pregnancy is otherwise normal(4). The presence of CB on early first-trimester ultrasound increases threefold the risk of miscarriage and adverse pregnancy outcomes, making it an ultrasound marker that requires a close surveillance throughout the pregnancy to prevent the long-term complications and provide adequate counseling to the patient(5).

The most common sonographic findings of CB are a protrusion from the chorionic wall into the gestational sac, having a central hypoechoic region and a peripheral hyperechoic rim, with no vascularity; a less comon aspect is a hyperechoic protrusion with no vascularity(6).

The purpose of this paper is to present a case diagnosed with chorionic bump at early stage of gestation and to review the data available in literature regarding this entity and the perinatal outcomes of pregnancies associated with it.

Case presentation
Figure 1. Transvaginal scan showing the gestational sac, the yolk sac and the round hypoechogenic image with a hyperchogenic border (the chorionic bump)

Figure 2. Second ultrasound examination, two weeks later. The embryo is visible within the gestational sac and the chorionic bump has not changed its so­no­gra­phic appearance
Figure 2. Second ultrasound examination, two weeks later. The embryo is visible within the gestational sac and the chorionic bump has not changed its so­no­gra­phic appearance


Figure 3. Typical ultrasound aspect of the chorionic bump as a bulge from the choriodecidual surface into the gestational sac
Figure 3. Typical ultrasound aspect of the chorionic bump as a bulge from the choriodecidual surface into the gestational sac

A 27-year-old Caucasian, gravida 1 (births 0, abortus 0), with 5 weeks and 2 days of amenorrhea and a positive urinary pregnancy test, presented in our department of fetal medicine for an early scan. The pregnancy was spontaneous and planned. The patient’s medical history was uneventful. The transvaginal ultrasound examination revealed an unique intrauterine gestational sac, the yolk sac and a round hypoechogenic image with a hyperchogenic border withing the gestational sac measuring 1.4/1.3 cm (Figure 1). Upon color and power Doppler examination, no vascular flow was detected. The seric concentration of free beta-HCG was 107,516.99 mUI/mL. The patient was rescanned after two weeks and a live embryo became visible with a CRL of 9.9 mm (corresponding to 7 weeks and 1 day). The sonographic appearance and size of the echogenic mass remained unchanged (Figures 2 and 3). We established that the diagnosis was a chorionic bump and the patient was counseled on the available data existing in literature regarding this obstetric complication. The patient opted for surgical termination of pregnancy (dilatation and curettage) and the embryonic karyotype came back normal (46, XY). The patient was discharged and is currently attempting to conceive again.


Chorionic bump is a rare condition usually diagnosed in the first trimester of pregnancy as a bulge from the choriodecidual surface into the gestational sac. It often decreases in size with time and rarely persists beyond the first trimester(7), although a recent case has been described being diagnosed in the third trimester(3).

The clinical significance and etiology of the CB remain unclear. The existing data hypothesize that the CB might be a hematoma, which has been consistently supported by sonographic findings and histopathological analysis(6). Baalman et al. were of the opinion that the mechanism behind chorionic bumps was the extensive necrosis of the decidualized endometrium(8).

While some authors suggest that a chorionic bump detected during the 11-week to 13-week scan is a transient, incidental finding with probably no relevant clinical significance(9), a recent systematic review and meta-analysis which included 173 pregnant women with CB and 1263 pregnant women without CB (control group) showed that the presence of CB at the first-trimester ultrasound significantly increased the risk of miscarriage and adverse pregnancy outcomes and reduced the rate of live newborns(5). After presenting all this information to our patient, she decided to terminate the pregnancy, in consequence we were unable to make any comments regarding the pregnancy outcome.

Another recent paper published by Lu et al. revealed that an increased incidence of chorionic bump was observed in patients with intrauterine operations and/or adverse maternal history. The early detection of CB, bigger relative size and multiple lesions are factors likely to be associated with poorer pregnancy outcomes(10).

Wax et al. demonstrated in their study that a sonographically isolated CB is associated with a significantly increased likelihood of aneuploidy in high-risk fetuses(11). Two pregnancies having CB were subsequently diagnosed with complete mole and trisomy 18, respectively, and the authors hypothesized that placental pathology (including edema and hydropic villi) may contribute to or cause the ultrasound findings of some CB(12).

The coexistence of neural tube defects (acrania) and CB was reported and this association was potentially attributed to folate deficiency(13). In our case, the patient opted for karyotype of the embryo and, thus, aneuploidy was excluded. There is no specific management or guidelines for preg­nancies diagnosed with CB and it remains unclear whether there is an intervention that might reduce the risk of miscarriage in affected patients(6). Due to the asso­cia­ted risk of  poor obstetric outcome, these cases should be followed-up with serial ultrasound examinations throughout the pregnancy(14).


We presented in our paper a case of chorionic bump diagnosed sonographically early in pregnancy and also the newest data published on this relatively rare condition. The clinical inference is that CB on first-trimester sonography does not guarantee a secure prediction and it is important to consider it as an ultrasound marker that requires close surveillance throughout pregnancy in order to prevent complications and be able to provide adequate couseling to the patients. 


Conflict of interests: The authors declare no con­flict of interests.


  1. Harris RD, Couto C, Karpovsky C, Blanchette Porter MM, Ouhilal S. The chorionic bump: A first-trimester pregnancy sonographic finding with a guarded progno­sis. J Ultrasound Med. 2006;25(6):757-63.
  2. Sana Y, Appiah A, Davison A, Nicolaides KH, Johns J, Ross JA. Clinical significance of first-trimester chorionic bumps: a matched case-control study. Ultrasound Obstet Gynecol. 2013;42(5):585-9.
  3. Mirghani MH, Wadhwa N, Jahangir F, Abdel Hak OW, Uppal S. Case report: cho­rio­nic bump detected in the third trimester. J Clin Ultrasound. 2022;50(1):82-5.
  4. Younesi L, Shahnazari R. Chorionic bump in first-trimester sonography. J Med Ultrasound. 2017;25(4):221-6.
  5. Vena F, Bartolone M, D’Ambrosio V, et al. Pregnancy and perinatal outcomes in pregnancy with diagnosis of chorionic bump on first-trimester sonography: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2021 Nov 22;1-8.
  6. Yousaf A, Tayyab A, Anil MSU, et al. Chorionic bump: radiologic features and pregnancy outcomes. Cureus. 2020;12(11):e11480.
  7. Carvalho RS, Osorio M, Brito C, Valente F. Chorionic bump in a pregnant patient with a history of infertility. BMJ Case Rep. 2018:bcr2018225091.
  8. Baalmann CG, Galgano SJ, Pietryga JA, Novak L, Robbin ML. A case of a chorionic bump: new sonographic-histopathologic findings with review of the literature. 
  9. J Ultrasound Med. 2017;36:1968-70.
  10. Sepulveda W. Chorionic bump at 11 to 13 weeks’ gestation: prevalence and cli­ni­cal significance. Prenat Diagn. 2019;39(6):471-6.
  11. Lu Yu, Wu Y, Huang F, Ren M. A single-center retrospective study of the clinical significance of chorionic bump at early stage of gestation. Am J Reprod Immunol. 2021;85(3):e13346.
  12. Wax JR, Cartin A, Litton C, Pinette MG, Lucas FL. First-trimester chorionic bump – 
  13. association with fetal aneuploidy in a high-risk population. J Clin Ultrasound. 2017;45(1):3-7.
  14. Wax JR, Blaszyk H, Jones M, Cartin A, Pinette MG. The chorionic bump: etiologic insights from two pathologic pregnancies. J Clin Ultrasound. 2016;44(7):452-4.
  15. Wegrzyn P, Brawura-Biskupski-Samaha R, Borowski D, Gorski A, Wielgos M. The 
  16. chorionic bump associated with acrania – case report. Ginekol Pol. 2013;84(12):1055-8.
  17. Tan ST, Ipek A, Sivaslioglu A, et al. The chorionic bump: radiologic and patho­lo­gic correlation. J Clin Ultrasound. 2011;39:35-7.

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