Acasa > Reviste de specialitate > Infectio.ro > Sarcomul Kaposi în infecţia HIV/SIDA – aspecte epidemiologice şi etiopatogenice

Sarcomul Kaposi în infecţia HIV/SIDA – aspecte epidemiologice şi etiopatogenice

 AIDS-related Kaposi sarcoma; epidemiological and etiopathogenic aspects

Mircea Ioan Popa, Simona Roxana Georgescu, Alexandra Limbău, Ela Muşa, P Andrei, MD Tanasescu, Mircea Tampa

First published: 20 noiembrie 2016

Editorial Group: MEDICHUB MEDIA

Abstract

Epidemic Kaposi sarcoma (KS) is a vascular neoplasia with in situ malignancy, that serves as an AIDS defining illness and is associated with human herpes virus-8 (HHV-8). It has a multifocal nature, histologically presenting as a double proliferation of spindle cells and vascular spaces, probably of endothelial origin. AIDS-related Kaposi’s sarcoma is the most common malignancy in HIV-infected patients and is the most aggressive clinically form of the disease. The current researchers regarding the epidemiology and pathogenesis of Kaposi’s sarcoma aim to highlight therapeutic opportunities in both the developed and developing world.

Keywords
epidemic Kaposi sarcoma (KS), human herpes virus-8 (HHV-8), epidemiology

Rezumat

Sarcomul Kaposi epidemic, condiţie definitorie a sindromul imunodeficienţei dobândite (SIDA), este o neoplazie vasculară, cu malignitate in situ, asociată virusului herpetic uman tip 8 (HHV-8). Are un caracter multifocal, prezentându‑se histologic ca o dublă proliferare de celule fusiforme şi spaţii vasculare, cel mai probabil de origine endotelială. Forma asociată infecţiei HIV/SIDA este cea mai frecventă neoplazie întâlnită la pacienţii cu infecţie HIV şi reprezintă cea mai agresivă formă a bolii. Cercetările actuale privind epidemiologia şi patogeneza sarcomului Kaposi au scopul de a evidenţia noi oportunităţi terapeutice, atât în ţările dezvoltate, cât şi în cele în curs de dezvoltare.

Cuvinte cheie
arcomul Kaposi epidemic (SK) virusul herpetic uman tip 8 (HHV-8) epidemiologie

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