Sarcomul Kaposi în infecţia HIV/SIDA – aspecte epidemiologice şi etiopatogenice

 AIDS-related Kaposi sarcoma; epidemiological and etiopathogenic aspects

First published: 20 noiembrie 2016

Editorial Group: MEDICHUB MEDIA


Epidemic Kaposi sarcoma (KS) is a vascular neoplasia with in situ malignancy, that serves as an AIDS defining illness and is associated with human herpes virus-8 (HHV-8). It has a multifocal nature, histologically presenting as a double proliferation of spindle cells and vascular spaces, probably of endothelial origin. AIDS-related Kaposi’s sarcoma is the most common malignancy in HIV-infected patients and is the most aggressive clinically form of the disease. The current researchers regarding the epidemiology and pathogenesis of Kaposi’s sarcoma aim to highlight therapeutic opportunities in both the developed and developing world.

epidemic Kaposi sarcoma (KS), human herpes virus-8 (HHV-8), epidemiology


Sarcomul Kaposi epidemic, condiţie definitorie a sindromul imunodeficienţei dobândite (SIDA), este o neoplazie vasculară, cu malignitate in situ, asociată virusului herpetic uman tip 8 (HHV-8). Are un caracter multifocal, prezentându‑se histologic ca o dublă proliferare de celule fusiforme şi spaţii vasculare, cel mai probabil de origine endotelială. Forma asociată infecţiei HIV/SIDA este cea mai frecventă neoplazie întâlnită la pacienţii cu infecţie HIV şi reprezintă cea mai agresivă formă a bolii. Cercetările actuale privind epidemiologia şi patogeneza sarcomului Kaposi au scopul de a evidenţia noi oportunităţi terapeutice, atât în ţările dezvoltate, cât şi în cele în curs de dezvoltare.


  1. Schwartz RA, Micali G, Nasca MR, Scuderi L. Kaposi sarcoma: a continuing conundrum. J Am Acad Dermatol. 2008;59(2):179-206.
  2. Mesri EA, Cesarman E, Boshoff C. Kaposi’s s arcoma and its associated herpesvirus. Nat rev Cancer. 2010;10(10):707-19..
  3.  Avey D, Brewers B, Zhu F. Recent advances in the study of Kaposi’s sarcoma - associated herpesvirus replication and pathogenesis. Virologica Sinica. 2015;30(2):130-45.
  4. Stiller CA, Trama A, Brewster DH, et al. Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project. Cancer epidemiology. 2014;38(6):670-8.
  5. Benhammane H, Mentha G, Tschanz E, et al. Viscer al Kaposi’s Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review. Case reports in oncological medicine. 2012;2012:137291.
  6. Simard EP, Engels EA. Cancer as a cause of death among people with AIDS in the United States. Clin Inf Dis. 2010;51(8):957-62.
  7. Reddy D, Mitsuyasu R. HIV-associated multicentric Castleman disease. Current Opin Oncol. 2011;23(5):475-81.
  8. Semeere AS, Busakhala N, Martin JN. Impact of antiretroviral therapy on the incidence of Kaposi’s sarcoma in resource-rich and resource-limited settings. Current Opin Oncol. 2012;24(5):522-30.
  9. Lee AJ, Brenner L, Mourad B, et al. Gastrointestinal Kaposi’s sarcoma: Case report and review of the literature. World J Gastrointestinal Pharmacology Therapeutics. 2015;6(3):89-95.
  10. Machado PR, Farias KJ, Genre J, et al. Disseminated Kaposi’s sarcoma in patients with HIV infection correlates to high serum levels of IL-10. Viral immunology. 2014;27(7):356-60.
  11. Bell BM, Syed A, Carmack SW, Thomas CA, Layton KF. Disseminated Kaposi sarcoma with osseous metastases in an HIV-positive patient. Proceedings. 2016;29(1):52-4.
  12. Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. The Journal of clinical investigation. 2010;120(4):939-49.
  13. Mbulaiteye SM, Parkin DM, Rabkin CS. Epidemiology of AIDS-related malignancies an internation al perspective. Hematology/oncology clinics of North America. 2003;17(3):673-96.
  14.  Armstrong AW, Lam KH, Chase EP. Epidemiology of classic and AIDS-rel ated K aposi’s sarcoma in the USA: incidence, survival, and geographical distribution from 1975 to 2005. Epidemiology and infection. 2013;141(1):200-6.
  15. Kamyab K, Ehsani AH, Azizpour A, et al. Demographic and histopathologic study of Kaposi’s sarcoma in a dermatology clinic in the years of 2006 to 2011. Acta medica Iranica. 2014;52(5):381-4.
  16. Minhas V, Wood C. Epidemiology and transmission of Kaposi’s sarcoma- associated herpesvirus. Viruses. 2014;6(11):4178-94.
  17. European Centre for Disease Prevention and Control/WHO Region al Office for Europe. HIV/ AIDS surveill ance in Europe 2011. Stockholm ECfDPaC, 2015.
  18. Huang G, Low G. Human Herpes Virus-8- Associated Multicentric Castleman’s Disease in a Human Immunodeficiency Virus-Positive Patient with a Previous History of Kaposi’s Sarcoma. Journal of clinical imaging science. 2015;5:59.
  19. Dow DE, Cunningham CK, Buchanan AM. A Review of Human Herpesvirus 8, the Kaposi’s Sarcoma – Associated Herpesvirus, in the Pediatric Population. J Ped Inf Dis Soc. 2014;3(1):66-76.
  20. Jha HC, LuJ, Verma SC, et al. Kaposi’s sarcoma- associated herpesvirus genome programming during the early stages of primary infection of peripheral blood mononuclear cells. mBio. 2014;5(6).
  21. De Paoli P, Carbone A. Kaposi’s Sarcoma Herpesvirus: twenty years after its discovery. Eur Rev Med Pharm Sci. 2016;20(7):1288-94.
  22. Cavallin LE, Goldschmidt-Clermont P, Mesri EA. Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi’s sarcoma associated with HIV/AIDS. PLoS Pathogens. 2014;10(7):e1004154.
  23. Matta H, Gopalakrishnan R, Graham C, et al. Kaposi’s sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-kappaB pathway independent of TRAF6, TAK1 and LUBAC. PloS One. 2012;7(5):e36601.
  24. Polizzotto MN, Uldrick TS, Wang V, et al. Human and viral interleukin-6 and other cytokines in Kaposi sarcom a herpesvirus-associated multicentric Castleman disease. Blood. 2013;122(26):4189-98.
  25. Gelgor A, Kalt I, Bergson S, et al. Viral Bcl-2 Encoded by the Kaposi’s Sarcoma- Associated Herpesvirus Is Vital for Virus Reactivation. Journal of virology. 2015;89(10):5298-307

Articole din ediţiile anterioare

SINTEZE | Ediţia 1 49 / 2017

Tuberculoza, după 135 de ani de la descoperirea bacilului Koch

Silvana-Adelina Gheorghe, Mădălina Preda, Gabriela-Loredana Popa, Mircea Ioan Popa

Tuberculosis, 135 years after the discovery of Koch’s Bacillus Suggested citation for this article: Gheorghe SA, Preda M, Popa GL, Popa MI. Tuberc...

26 aprilie 2017