RUBRICA SPECIALISTULUI

Intoleranţa la histamină

 Histamine intolerance

First published: 31 octombrie 2023

Editorial Group: MEDICHUB MEDIA

DOI: 10.26416/Aler.7.3.2023.8791

Abstract

Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required to help define, diagnose and clinically manage this condition. This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing diagnostic, differential diagnoses and treatment strategies.
 

Keywords
histamine intolerance, histamine, diamine oxidase, DAO, low-histamine diet, probiotics, food intolerance

Rezumat

Intoleranţa la histamină, denumită şi histaminoză enterală sau sensibilitate la alimente care conţin histamină, este o tulburare asociată cu o capacitate deficitară de a metaboliza histamina ingerată, care a fost descrisă la începutul secolului XXI. Deşi interesul pentru intoleranţa la histamină a crescut considerabil în ultimii ani, sunt încă necesare mai multe dovezi ştiinţifice pentru a ajuta la definirea, diagnosticarea şi gestionarea clinică a acestei afecţiuni. Articolul de faţă prezintă o analiză actualizată a intoleranţei la histamină, concentrându-se în principal pe etiologia acesteia şi pe strategiile de diagnostic, diagnostic diferenţial şi tratament existente.
 

Bibliografie

 
  1. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020 Aug 14;10(8):1181. doi: 10.3390/biom10081181. 2.
  2. EFSA Panel on Biological Hazards (BIOHAZ). Scientific Opinion on risk based control of biogenic amine formation in fermented foods. EFSA J. 2011;9:1–93.
  3. Reese I, Ballmer-Weber B, Beyer K, et al. German guideline for the management of adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Association of Allergologists (AeDA), and the Swiss Society for Allergology and Immunology (SGAI). Allergo J Int. 2017;26(2):72-79. doi: 10.1007/s40629-017-0011-5. .
  4. Windaus A, Vogt W. Synthese des Imidazolyl-äthylamins. Berichte der Dtsch Chem. Gesellschaft. 1907;40:3691–369.5
  5. Hrubisko M, Danis R, Huorka M, et al. Histamine Intolerance – The More We Know the Less We Know. A Review. Nutrients. 2021 Jun 29;13(7):2228. doi: 10.3390/nu13072228. .
  6. Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y. Histamine: neural circuits and new medications. Sleep. 2019 Jan 1;42(1):zsy183. doi: 10.1093/sleep/zsy183. .
  7. Kucher AN. Association of Polymorphic Variants of Key Histamine Metabolism Genes and Histamine Receptor Genes with Multifactorial Diseases. Russ J Genet. 2019;55:794-814. https://doi.org/10.1134/S102279541907010X
  8. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96. doi: 10.1093/ajcn/85.5.1185. .
  9. Boehm T, Pils S, Gludovacz E,e t al. Quantification of human diamine oxidase. Clin Biochem. 2017 May;50(7-8):444-451. doi: 10.1016/j.clinbiochem.2016.12.011. .
  10. Elmore BO, Bollinger JA, Dooley DM. Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79. doi: 10.1007/s00775-001-0331-1. .
  11. Finney J, Moon HJ, Ronnebaum T, et al. Human copper-dependent amine oxidases. Arch Biochem Biophys. 2014 Mar 15;546:19-32. doi: 10.1016/j.abb.2013.12.022. .
  12. Schwelberger HG, Feurle J, Houen G. Mapping of the binding sites of human histamine N-methyltransferase (HNMT) monoclonal antibodies. Inflamm Res. 2017 Nov;66(11):1021-1029. doi: 10.1007/s00011-017-1086-7. .
  13. Kovacova-Hanuskova E, Buday T, Gavliakova S, Plevkova J. Histamine, histamine intoxication and intolerance. Allergol Immunopathol (Madr). 2015 Sep-Oct;43(5):498-506. doi: 10.1016/j.aller.2015.05.001. .
  14. McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM. Structure and inhibition of human diamine oxidase. Biochemistry. 2009 Oct 20;48(41):9810-22. doi: 10.1021/bi9014192. 1.
  15. Ji Y, Sakata Y, Li X, et al. Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 15;304(8):G732-40. doi: 10.1152/ajpgi.00399.2012. .
  16. García-Martín E, Ayuso P, Martínez C, et al. Histamine pharmacogenomics. Pharmacogenomics. 2009 May;10(5):867-83. doi: 10.2217/pgs.09.26. .
  17. Maintz L, Yu CF, Rodríguez E, et al. Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy. 2011 Jul;66(7):893-902. doi: 10.1111/j.1398-9995.2011.02548.x. .
  18. Miyoshi J, Miyamoto H, Goji T, et al. Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs. J Gastroenterol Hepatol. 2015 Nov;30(11):1582-90. doi: 10.1111/jgh.13004. .
  19. Sattler J, Häfner D, Klotter HJ, et al. Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents Actions. 1988 Apr;23(3-4):361-5. doi: 10.1007/BF02142588. .
  20. Komericki P, Klein G, Reider N, et al. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. Wien Klin Wochenschr. 2011 Jan;123(1-2):15-20. doi: 10.1007/s00508-010-1506-y. 2.
  21. Alnouri G, Cha N, Sataloff RT. Histamine Sensitivity: An Uncommon Recognized Cause of Living Laryngopharyngeal Reflux Symptoms and Signs – A Case Report. Ear Nose Throat J. 2022 May;101(4):NP155-NP157. doi: 10.1177/0145561320951071. .
  22. Ansaranta M, Kauppi P, Malmberg LP, et al. Inspiratory and Expiratory Flow Changes, Voice Symptoms and Laryngeal Findings during Histamine Challenge Tests. Folia Phoniatr Logop. 2020;72(1):29-35. doi: 10.1159/000495783. .
  23. Colombo B, Filippi M. Migraine and literature: a narrative historical review. Neurol Sci. 2021 Feb;42(2):565-569. doi: 10.1007/s10072-020-05014-z. .
  24. Esposito F, Montuori P, Schettino M, et al. Level of Biogenic Amines in Red and White Wines, Dietary Exposure, and Histamine – Mediated Symptoms upon Wine Ingestion. Molecules. 2019 Oct 8;24(19):3629. doi: 10.3390/molecules24193629. 2.
  25. Płotka-Wasylka J, Simeonov V, Namieśnik J. Evaluation of the Impact of Storage Conditions on the Biogenic Amines Profile in Opened Wine Bottles. Molecules. 2018 May 9;23(5):1130. doi: 10.3390/molecules23051130. 26.
  26. San Mauro Martin I, Brachero S, Garicano Vilar E. Histamine intolerance and dietary management: A complete review. Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):475-83. doi: 10.1016/j.aller.2016.04.015. .
  27. Maykish A, Rex R, Sikalidis AK. Organic Winemaking and Its Subsets; Biodynamic, Natural, and Clean Wine in California. Foods. 2021 Jan 8;10(1):127. doi: 10.3390/foods10010127. .
  28. Schnedl WJ, Enko D. Histamine Intolerance Originates in the Gut. Nutrients. 2021 Apr 12;13(4):1262. doi: 10.3390/nu13041262. .
  29. Jaros J, Shi VY, Katta R. Diet and Chronic Urticaria: Dietary Modification as a Treatment Strategy. Dermatol Pract Concept. 2019 Dec 31;10(1):e2020004. doi: 10.5826/dpc.1001a04. . 
  30. Wagner N, Dirk D, Peveling-Oberhag A, et al. A Popular myth - low-histamine diet improves chronic spontaneous urticaria - fact or fiction? J Eur Acad Dermatol Venereol. 2017 Apr;31(4):650-655. doi: 10.1111/jdv.13966. 1.
  31. Yacoub MR, Ramirez GA, Berti A, et al. Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study. Int Arch Allergy Immunol. 2018;176(3-4):268-271. doi: 10.1159/000488142. .
  32. Schnedl WJ, Tillich M, Schenk M, et al. Food intolerance/malabsorption may occur in rare diseases. Intractable Rare Dis Res. 2020 May;9(2):126-129. doi: 10.5582/irdr.2020.01029. .
  33. Stolze I, Peters KP, Herbst RA. Histaminintoleranz imitiert Anorexia nervosa [Histamine intolerance mimics anorexia nervosa]. Hautarzt. 2010 Sep;61(9):776-8. German. doi: 10.1007/s00105-009-1869-z. .
  34. Chung BY, Cho SI, Ahn IS, et al. Treatment of Atopic Dermatitis with a Low-histamine Diet. Ann Dermatol. 2011 Sep;23 Suppl 1(Suppl 1):S91-5. doi: 10.5021/ad.2011.23.S1.S91. .
  35. Vassilopoulou E, Konstantinou GN, Dimitriou A, et al. The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study. Nutrients. 2020 Nov 5;12(11):3402. doi: 10.3390/nu12113402. .
  36. Bai T, Wang WF, Zhang L, et al. Positive endoscopic and ultrasonographic findings in patients with symptom-diagnosed functional gastrointestinal disorder: Data from a Chinese cross-sectional study. J Dig Dis. 2018 Dec;19(12):759-765. doi: 10.1111/1751-2980.12693. 3.
  37. Tuck CJ, Biesiekierski JR, Schmid-Grendelmeier P, Pohl D. Food Intolerances. Nutrients. 2019 Jul 22;11(7):1684. doi: 10.3390/nu11071684. .
  38. Amon U, Bangha E, Küster T, et al. Enteral histaminosis: Clinical implications. Inflamm Res. 1999 Jun;48(6):291-5. doi: 10.1007/s000110050462. 9.
  39. Reese I, Ballmer-Weber B, Beyer K, et al. German guideline for the management of adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Association of Allergologists (AeDA), and the Swiss Society for Allergology and Immunology (SGAI). Allergo J Int. 2017;26(2):72-79. doi: 10.1007/s40629-017-0011-5. 0.
  40. Mušič E, Korošec P, Šilar M, et al. Serum diamine oxidase activity as a diagnostic test for histamine intolerance. Wien Klin Wochenschr. 2013 May;125(9-10):239-43. doi: 10.1007/s00508-013-0354-y. 1.
  41. Manzotti G, Breda D, Di Gioacchino M, et al. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. 4.
  42. Kung HF, Lee YC, Huang YL, et al. Degradation of Histamine by Lactobacillus plantarum Isolated from Miso Products. J Food Prot. 2017 Oct;80(10):1682-1688. doi: 10.4315/0362-028X..
  43. Schnedl WJ, Schenk M, Lackner S, et al. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019 May 24;28(6):1779-1784. doi: 10.1007/s10068-019-00627-3. .
  44. Pinzer TC, Tietz E, Waldmann E, et al. Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls. Allergy. 2018 Apr;73(4):949-957. doi: 10.1111/all.13361. .
  45. Aschenbach JR, Honscha KU, von Vietinghoff V, et al. Bioelimination of histamine in epithelia of the porcine proximal colon of pigs. Inflamm Res. 2009 May;58(5):269-76. doi: 10.1007/s00011-008-8091-9. .
  46. Wöhrl S, Hemmer W, Focke M, et al. Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Allergy Asthma Proc. 2004 Sep-Oct;25(5):305-11. .
  47. Komericki P, Klein G, Reider N, et al. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. Wien Klin Wochenschr. 2011 Jan;123(1-2):15-20. doi: 10.1007/s00508-010-1506-y. .
  48. Mennigen R, Kusche J, Streffer C, et al. Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients. Agents Actions. 1990 Apr;30(1-2):264-6. doi: 10.1007/BF01969056. .
  49. García-Martin E, Mendoza JL, Martínez C, et al. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. World J Gastroenterol. 2006 Jan 28;12(4):615-20. doi: 10.3748/wjg.v12.i4.615. .
  50. López Palacios N, Agúndez JA, Mendoza JL, et al. Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn’s disease. Scand J Gastroenterol. 2009;44(10):1207-12. doi: 10.1080/00365520903171250. .
  51. Lackner S, Malcher V, Enko D, et al. Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. Eur J Clin Nutr. 2019 Jan;73(1):102-104. doi: 10.1038/s41430-018-0260-5. .
  52. Yacoub MR, Ramirez GA, Berti A, et al. Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study. Int Arch Allergy Immunol. 2018;176(3-4):268-271. doi: 10.1159/000488142. .
  53. Rosell-Camps A, Zibetti S, Pérez-Esteban G, et al. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. doi: 10.4321/s1130-01082013000400004. 

Articole din ediţiile anterioare

PREZENTARE DE CAZ | Ediţia 4 4 / 2020

Un caz de edem facial poate fi o provocare de diagnostic şi tratament

Bara Noémi-Anna , Șef lucrări Dr. Nădăşan Valentin

Angioedemul este o reacţie locală, autolimitată la nivelul ţesutului subcutanat şi/sau submucos, cauzată de creşterea temporară a permeabilităţii v...

22 decembrie 2020
REFERATE GENERALE | Ediţia 1 5 / 2021

Sindromul de activare mastocitară – tablou clinic şi criterii de diagnostic

Elena-Simona Boldeanu, Mădălina Avram, Lucian Rezmeriţă

Sindromul de activare mastocitară (SAM) este o tulburare multisistemică cronică, insuficient recunoscută şi diagnosticată, rezultat al activării ne...

31 martie 2021
LUCRĂRI ORIGINALE | Ediţia 4 4 / 2020

Angioedemul idiopatic – dificultăţi de abordare clinică şi terapeutică

Prof. dr. Polliana Mihaela Leru, Corina Marton

Angioedemul reprezintă tumefierea localizată şi autolimitată a straturilor profunde ale dermului, a ţesutului subcutanat ori a ţesutului submucos (...

22 decembrie 2020