Chronic spontaneous urticaria (CSU) is a common pathology with a prevalence of 1-2% in the population. Chronic underlying infection and mental and emotional stress can sometimes precede the onset of CSU and once established can exacerbate the symptoms. The most common comorbidities are autoimmune thyroiditis, vitiligo, atopic pathology, chronic inflammation and psychiatric disorders, such as depression and anxiety. Omalizumab has been shown to be effective and safe with a high response rate and it is the treatment of choice for antihistamine-resistant patients. We will present a series of 12 cases of patients from our clinic who have been on omalizumab therapy and their associated pathologies.